Klopp has won many plaudits for his team's style of football, but his Liverpool side have lost in two finals - the League Cup and the Europa League in 2016.
If the German worldwide and his team-mates needed any extra motivation ahead of the tie, it lies in the fact that City's sole defeat in the Premier League this season came at the hands of the Merseysiders with Liverpool edging a seven-goal Anfield thriller in January.
That may have been a dress rehearsal for Wednesday's game where, whoever Guardiola chooses as the left-back will have the daunting task of marking Mohamed Salah, who has scored 37 goals in all competitions this season.
Although he has led Liverpool back into the Champions League, the German knows he must deliver trophies.
If anyone can beat City, Liverpool at least know they have a blueprint which works and that is why Guardiola cannot place an iota of importance on the United game.
If we are able [we make the] semi-finals, if we are not able [we say] well done Liverpool and next season we come back stronger to overcome the situation we can not this season.
"I was never a manager who thought what is the best result?"
"The other team is Sevilla, since we already played there".
Viral condom-snorting challenge is risky
Most of the 152 incidents involving condoms - 107 cases, to be exact - were related to ingestion, according to the statistics. On the heels of the Tide Pod challenge comes a very unsafe new craze on social media: the condom-snorting challenge.
But the City fanbase has still to embrace the Champions League and regard it as the pinnacle, as they do at Anfield and Old Trafford, so local supremacy remains the primary focus for many of them. We should finish the game with 11 first of all, that would be cool.
"But that's a big ask, to be able to put that much energy and effort in two games, for 90 minutes a time".
Rather than leaving that condition hanging in the air he quickly stressed that Liverpool's task is "unbelievably difficult". The Champions League is where Guardiola's focus should be. Hopefully he can help us.
The Catalan revealed following Saturday's victory at Goodison Park that all of his decisions over the next 10 days will be made with both games against Liverpool in mind.
I hope I can earn back respect: Steve Smith
Cricket Australia CEO James Sutherland apologized on behalf of the organization, to both Australia and South Africa. Cricket Australia, however, is expected to officially confirm the announcement of their penalties later today.
Israeli PM Netanyahu hospitalized with fever
A security cabinet meeting scheduled for Wednesday will take place as planned, an Israeli official told Reuters . Support for Netanyahu's Likud party remains strong in opinion polls.
Huawei triples up cameras
Unlike the lenses of its rivals, Huawei has opted against optical stabilization on the P20 Pro's two main rear cameras . Huawei is under scrutiny from the United States government and has a hard time selling its smartphones because of that.