It leaves United six points clear at the top of Group A with two matches remaining on a night that started with Mourinho taking aim at some of his club's supporters in the programme.
However, Lukaku has failed to score in his last three outings and even elicited groans from the home fans during Saturday's 1-0 win over Tottenham, despite providing the assist for Anthony Martial's victor.
"So for me untouchable in my team and also untouchable in the respect and support he deserves from the fans".
"He is a young player who is showing huge progression and significant development", said Vitoria of the 20-year-old, who only made his first senior appearance for Benfica in September. "What we can not do is play with 12 players, and we can not play with everybody at the same time".
The United boss always adopts a reactionary stance in big games and rarely goes all guns blazing, preferring to kill off the game and maybe steal a goal.
The Belgian global hit the ground running at Old Trafford following his £75m off-season move from Everton, scoring seven goals in his first seven Premier League matches.
United's best chance of denying local rivals City the title this season is to commit to Mourinho's trademark style - an approach that saw him win league titles in his second season in charge of Chelsea, Inter Milan and Real Madrid.
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