Jhal Magsi is located at a three-hour drive from Jacobabad and Larkana.
Sarfraz Bugto, the provincial home minister, said "terrorists have shown their inhumaneness by attacking innocent civilians".
DPO Jhal Magsi said a constable was killed while attempting to stop the suicide bomber from entering the shrine.
There was no immediate claim of responsibility but militants and separatists have repeatedly targetted minority Shiite Muslims at religious sites, as well as security officials.
Uber London licence: 'Direct anger at firm' says mayor
Transport for London (TfL) cited " public safety and security implications " among its reasons for denying Uber's license. The initial background checks were carried out by a third party but TfL deemed them inadequate following a review.
"We have confirmed reports it was a suicide attack", he said.
The local administration has declared an emergency at hospitals in Sibbi and Dera Murad Jamali.
Pakistani Prime Minister Shahid Khaqan Abbasi condemned the attack, saying that "terrorists have no religion" and that his government will act against militants with full might.
The attack, which came as the latest sectarian attack in troubled Baluchistan province, is also the second major attack at a shrine in Balochistan in a year.
WAFU Cup 2017: Black Stars humiliate Eagles
After Ghana's 4-1 defeat of Nigeria, there were media reports that Enyimba had started talks with the coach, who is also an assistant manager in the main Black Stars' team.
Todays attack is the second major strike at a shrine in Balochistan where in November 2016, at least 52 people were killed and 102 injured in a blast at the shrine of Shah Norani in Khuzdar district.
Catalonia on streets after Spain's arrests
He said the measure "does not mean taking command" of the Catalan police, but it is "simply to agree on a means of coordination". That support has been waning in recent months as Spain's national and regional economies have begun thriving again.
North Korea quake not a nuclear test, say China experts
Chinese banks were told this week to refuse new clients from North Korea and begin winding down business with existing customers. North Korea in past months has been stepping up the aggressiveness of its nuclear and missile tests. "This could change that".
Prince Harry Robbed Blind By Tiny Popcorn Thief
Harry last visited the Honeymoon Capital in 1991 along with his late mother Princess Diana and his brother Prince William. Prince Harry's girlfriend is now not entitled to taxpayer-funded protection as she is not a member of the royal family.
Hatch Bill To Renew CHIP Funding Passes Senate Committee
We're certainly not taking anything for granted. "We're still holding out hope for a bipartisan deal", Hand said Monday afternoon. Nine million kids across the country may be uninsured after congress allowed the Children's Health Insurance Program to expire.
Sending our love to the lovely island of Puerto Rico
Rossello also noted that he has been speaking with members of Congress from both parties in order to achieve a seven-day waiver. The conference was held amid growing criticism that Trump had not mentioned Puerto Rico or the USVI for several days.
New Firefox Quantum Browser Gets Official
Menus and tabs have been redesigned, while a new "library" button pulls together bookmarks, downloads and history into one place. Browser maker Mozilla hopes to regain some momentum with the release of a souped-up version of its flagship Firefox browser .
Texas at Iowa State
Texas coach Tom Herman gave credit to Iowa State's defensive game plan and acknowledged his team's mistakes and shortcomings. The teams combined for 568 total yards and 37 first downs, which is about one team's total in a typical Big 12 game.